by Sarah Kuta
Last updated: 9:15 AM ET, Tue September 23, 2025
American Cruise Lines is launching three new itineraries on the Mississippi River and its tributaries.
The new cruises include a nine-day Arkansas River cruise between Tulsa, Oklahoma, and Memphis, Tennessee; an 11-day Great Smoky Mountains cruise between Knoxville and Huntsville, Tennessee; and an eight-day Gulf Coast cruise between Pensacola, Florida, and New Orleans, Louisiana.
Each itinerary also includes a pre-cruise hotel stay.
In total, American Cruise Lines now offers 14 itineraries, plus additional themed and holiday cruises, on the Mississippi River.
The nine-day Arkansas River cruise will be offered in November 2026 aboard the American Serenade.
The 11-day Great Smoky Mountains cruise will be offered in July, August, September and October 2027 aboard the classic paddlewheeler, American Heritage.
The eight-day Gulf Coast cruise will be offered aboard American Symphony in March and December 2026, as well as March and December 2027. The voyage primarily sails along the Gulf’s Intracoastal Waterway but also sails the Mississippi River to and from New Orleans.
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